This vehicle is no longer listed, so the estimate starts from $39,633 — the typical market price for this build. Move the numbers to match your own loan.

Vehicle price

Down payment

10% down

Interest rate (APR)

7.0% is a typical rate for a well-qualified buyer — use your own quote if you have one.

Loan term

Estimated monthly payment

$706

per month

60 months · 7.0% APR · $3,963 down

Amount financed

$35,670

Total interest

$6,690

Estimate only. Excludes tax, title, registration and dealer fees, and assumes a fixed-rate loan with equal monthly payments. Your actual rate depends on your credit and lender.

Decoded from the VIN

NHTSA build data for 2T2YZMDA3MC283245

Trim

350 F SPORT

Engine

3.5L · V6

Horsepower

295

Drivetrain

4WD/4-Wheel Drive/4x4

Body

Sport Utility Vehicle (SUV)/Multi-Purpose Vehicle (MPV)

Fuel

Gasoline

Doors

Model year

2021

Made by

TOYOTA MOTOR MANUFACTURING CANADA

Full factory specs for this build →

✓ Backup camera
✓ Blind-spot monitor
✓ Lane departure
✓ ABS
✓ Electronic stability

Fuel economy (EPA)

Combined

MPG

City

MPG

Highway

MPG

$2,020 /yr est. fuel

Assumes 15,000 miles a year at $3.10/gallon and 23 MPG combined.

5-year cost to own

Beyond the sticker: what this 2021 Lexus RX 350 F S likely costs over five years at 15,000 mi/yr.

Depreciation $13,945

Fuel $10,100

Insurance $10,500

Maintenance & repairs $4,312

Total, 5 years $38,857

Estimate — insurance and taxes vary by driver and state.

Safety & recalls

NHTSA crash tests & recall campaigns for this model year

The 2021 Lexus RX 350 F S has 1 recall campaign as of September 2026. NHTSA rated it 4 out of 5 stars overall. EPA combined fuel economy: 23 MPG.

Overall

★★★★☆

4 of 5 · NHTSA

Frontal crash

★★★★☆

4 of 5 · NHTSA

Side crash

★★★★★

5 of 5 · NHTSA

Rollover

★★★★☆

4 of 5 · NHTSA

Tested configuration: 2021 Lexus RX 350 SUV FWD Later Release

1 recall campaign on this model year

Check accident & title history →

AIR BAGS

Toyota Motor Engineering & Manufacturing (Toyota) is recalling certain 2020-2021 Avalon, Avalon Hybrid, Corolla, Highlander, Highlander Hybrid, RAV4, RAV4 Hybrid, Lexus ES350,…

NHTSA campaign 23V865000

Recall campaigns apply to the model year, not to one car. Check remedy status for this VIN at nhtsa.gov/recalls.

Model-level data for the 2021 Lexus RX 350 F S from NHTSA (recalls, NCAP crash tests) and EPA fueleconomy.gov, refreshed September 1, 2026.